Endocrine Abstracts

Objective: This systematic review aimed to assess the efficacy and safety of testosterone replacement therapy (TRT) in obese men with testosterone deficiency through the analysis of randomized controlled trials (RCTs).Materials and Methods: A comprehensive computer-based search was conducted in Cochrane Library, PubMed, Embase, Web of Science, Scopus, Open SIGLE database, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP database, and Chi...

Background and purpose: Obese men often exhibit hypoandrogenemia. Although previous research has established obesity and metabolic-related disorders as key factors contributing to decreased androgens in males, there are rare studies to comprehensively understand the correlation between sex hormones and obesity, as well as metabolic indicators, particularly in non Caucasian populations. This study aims to comprehensively investigate the relationship between sex hormones and obe...

The caveolin (CAV) consists of three isoforms (CAV1, CAV2, and CAV3) and contributes to insulin-regulated glucose metabolism. It has been reported that decreased caveolin-1 phosphorylation in the endometrium is linked with insulin resistant state in women with polycystic ovary syndrome (PCOS). Because PCOS patients often display hyperandrogenism, whether hyperandrogenism in addition to insulin resistant is involved in the regulation of caveolin expression and activation in the...